Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - 5-HT Receptor - RS 102221

RS 102221

CAS No. 187397-18-8

RS 102221 ( RS102221;RS-102221 )

Catalog No. M12904 CAS No. 187397-18-8

A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    RS 102221
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.
  • Description
    A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively; demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors; acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2 mg/kg, i.p.); reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.
  • Synonyms
    RS102221;RS-102221
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    187397-18-8
  • Formula Weight
    649.08
  • Molecular Formula
    C27H31F3N4O7S.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.[H]Cl
  • Chemical Name
    8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bonhaus DW, et al. Neuropharmacology. 1997 Apr-May;36(4-5):621-9.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15;861:269.
3. Sévoz-Couche C, et al. Br J Pharmacol. 2000 Dec;131(7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1;21(19):7781-7.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CaCCinh-A01

    CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).

  • Lamotrigine

    Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder.

  • Gepirone

    Gepirone HCl is a compound of the azapirone group which is a 5-HT1A receptor agonist belonging to the buspirone family.

Sign In Join Free