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Home - Products - Endocrinology/Hormones - 5-HT Receptor - RS 102221

RS 102221

CAS No. 187397-18-8

RS 102221 ( RS102221;RS-102221 )

Catalog No. M12904 CAS No. 187397-18-8

A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RS 102221
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.
  • Description
    A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively; demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors; acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2 mg/kg, i.p.); reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.
  • Synonyms
    RS102221;RS-102221
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    187397-18-8
  • Formula Weight
    649.08
  • Molecular Formula
    C27H31F3N4O7S.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.[H]Cl
  • Chemical Name
    8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bonhaus DW, et al. Neuropharmacology. 1997 Apr-May;36(4-5):621-9.
2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15;861:269.
3. Sévoz-Couche C, et al. Br J Pharmacol. 2000 Dec;131(7):1445-53.
4. McMahon LR, et al. J Neurosci. 2001 Oct 1;21(19):7781-7.
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